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American Society of Microbiology ABMM Exam Syllabus Topics:

American Society of Microbiology ABMM Sample Questions:

1. A clinical microbiology laboratory is performing antimicrobial susceptibility testing on a Klebsiella pneumoniae isolate. The isolate is resistant to multiple beta-lactam antibiotics, and further testing reveals the presence of a carbapenemase enzyme. The MOST clinically significant carbapenemase in Klebsiella pneumoniae is often:

A) Extended-spectrum beta-lactamase (ESBL)
B) Metallo-beta-lactamase (MBL)
C) Klebsiella pneumoniae carbapenemase (KPC)
D) AmpC beta-lactamase

2. An immunocompromised patient develops a disseminated fungal infection. Blood cultures are consistently negative. However, a serum beta-D-glucan assay is markedly elevated. Tissue biopsy reveals the presence of hyaline, septate hyphae with dichotomous branching. The MOST likely causative organism is:

A) Rhizopus species
B) Mucor species
C) Aspergillus fumigatus
D) Cryptococcus neoformans

3. A microbiology laboratory receives a corneal scraping from a patient with keratitis. Microscopic examination with calcofluor white stain reveals the presence of septate hyphae and conidiophores with a foot cell and phialides. The MOST likely genus is:

A) Candida
B) Rhizopus
C) Aspergillus
D) Mucor

4. A patient with a history of chronic lung disease develops a severe pneumonia. Bronchoalveolar lavage fluid reveals the presence of numerous cysts containing multiple nuclei, which stain positively with silver stains but poorly with Gram stain. The patient's CD4+ T-cell count is within the normal range. The MOST likely causative organism and the preferred treatment are:

A) Paragonimus westermani; praziquantel.
B) Pneumocystis jirovecii; trimethoprim-sulfamethoxazole.
C) Histoplasma capsulatum; amphotericin B followed by itraconazole.
D) Blastomyces dermatitidis; itraconazole.

5. A neonate develops a vesicular rash, fever, and seizures within the first week of life. CSF analysis reveals lymphocytic pleocytosis and elevated protein. PCR of the CSF is positive for a double-stranded DNA virus.
The MOST likely causative agent is:

A) Cytomegalovirus (CMV)
B) Varicella-zoster virus (VZV)
C) Human parvovirus B19
D) Herpes simplex virus (HSV)

Solutions: